Off Parasol Ganglion Cell

References

• Postsynaptic connections (Input)
  • 85 Bipolar synapses (Calkins, Schein and Sterling; ARVO abstract 15, 1995)
    • 25 DB2 synapses
    • 60 DB3 synapses
  • 62 Amacrine synapses
    • ChAT-positive amacrine (non-displaced or displaced) cells - Jacoby and Marshak ARVO '96

• Presynaptic connections (Output)
  • LGN

• Function

• Morphology
  • Dendritic tree diameter - Human (Kolb, Linberg, Fisher, 1992)
    • Fovea: 25-30 um
    • 1.5 mm: 40 x 70 um eliptic
    • 3 mm: 110um
    • 8 mm: 160 um
    • 14 mm: 270 um
  • In peripheral retina: - Human (Kolb, Linberg, Fisher, 1992)
    • cell bodies: 25-30 um diameter
    • 2 or more large thick dendrites which branch
    • "The dendrites appear to be very planar and branch either in sublamina a (stratum 2) or sublamina b (stratum 3)"
    • Stout axons: 1.5-2 um thick

• Array characteristics
  • Peak density close to the fovea - Slveira and Perry (1991)

• Compartmental Model Characteristics

• Location
  Ganglion Cell Layer with dendrites in the 15-50% Inner Plexiform Layer and an Axon projecting to the LGN.

• Synapse types

• Synapse Receptors

• Neurotransmitters

• Immunoreactivity

• Nomenclature
  • Polyak ('41) originated the Parasol classification
  • M-cell or Magnocellular projecting ganglion cell
  • Human (Kolb, Linberg, Fisher, 1992)
    • P2 = Polyak's small Parasol
    • Ma: Polyak's Large parasol and giant cells with dendrites in sublamina a of the IPL.
    • Mb: Polyak's Large parasol and giant cells with dendrites in sublamina b of the IPL.

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  Lance Hahn (lance@retina.anatomy.upenn.edu)