Cat Bipolar cb1 (na3, CBa2, ?, ?)

References

• Postsynaptic connections (Input)
  • Cone Photoreceptor
    • 5 invaginating synapses per cone on 2 cones via cone ribbon synapses - McGuire, Stevens and Sterling (1984): 2 degrees
  • Horizontal Cell
  • Amacrine Cell
    • McGuire, Stevens and Sterling (1984): 2 degrees
      • AII (0, 3 synapses or 0%, 6% of sub A inputs)
      • Reciprocal synapse with Unkown Amacrine (9, 18 synapses or 18%,37% of sub A inputs)
      • Non-reciprocal synapse with Unkown Amacrine (42, 28 synapses or 85%, 57% of sub A inputs)
      • Totals: Cell #15 = 38, Cell #5 = 49

• Presynaptic connections (Output)
  • Amacrine Cell
    • McGuire, Stevens and Sterling (1984) - sublamina A outputs
      • AII (2,2 synapses or 4%,4% of sub A inputs)
      • Reciprocal synapse with Unkown Amacrine (5,9 synapses or 10%,21% of sub A inputs)
      • Non-reciprocal synapse with Unkown Amacrine (9,10 synapses or 19%, 23% of sub A inputs)
      • Amacrine Totals: Cell #15 = 33%,16 Cell #5 = 48%,20
      • Totals: Cell #15 = 47, Cell #5 = 42
    • Kolb and Nelson, 1984
      • A8
  • Ganglion Cell
    • McGuire, Stevens and Sterling (1984) - sublamina A outputs
      • Dark (probably Off-Beta/X) (13,12 synapses or 27%, 29% of sub A inputs)
      • Pale (probably Off-Alpha/Y) (9,1 synapses or 19%, 2% of sub A inputs)
      • Ganglion Cell Totals: Cell #15 = 46%,22 Cell #5 = 21%,9
      • Totals: Cell #15 = 47, Cell #5 = 42
    • Off-Beta/X ganglion cell via ribbon synapses (Kolb and Nelson, 1993)

  • Function
    • Presumably an off-bipolar (since IPL-A stratification) so hyperpolarizes to light
    • Karschin and Wassle (1990): "Light responses typically consist of graded and sustained potential changes of 20-25 mV from an average dark potential between -50 and -30 mV, without the occurrence of repeititive action potentials."

  • Morphology
    • Kolb, Nelson and Mariani (1981)
      • 30-60 um dendritic span - narrow-field
      • axon terminal is varicose with swellings as large as 5 um.
    • McGuire, Stevens and Sterling (1984): 2 degrees
      • 8.9 um soma diameter
      • bushy axon arborization
      • 2-3 um varicose swellings

  • Array characteristics

  • Compartmental Model Characteristics

  • Location
    • Kolb, Nelson and Mariani (1981)
      • Soma in the middle to lower part of the INL
      • stratified in the S1 of sublamina A of the IPL
    • McGuire, Stevens and Sterling (1984): 2 degrees
      • soma in center of INL
      • Axon ramified through S1 and S2 and top of S3 with most synaptic contacts in S1 of the IPL

  • Subclasses

  • Synapse types

  • Synapse Receptors

  • Neurotransmitters
    • Does not accumulate glycine. Cohen and Sterling '86
    • contains GABA plus glutamate (Vardi et al 96)

  • Immunoreactivity

  • Nomenclature
    • Kolb et al '81 named it cb1
    • They equated it to the varicose flat cone bipolar of Boycott and Kolb, 1973
    • McGuire et al '84 equated cb1 to their CBa2 and to Famiglietti '81s na3)

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  © 1995 Lance Hahn (lance@retina.anatomy.upenn.edu)