GABA (gamma-aminubutyric acid)

Function

• Thought of as inhibitory.

GABA-utilizing Cells (not certain how it is used)

• A2 Amacrine Cell
• A10 Amacrine Cell
• A13 Amacrine Cell
• A17 Amacrine Cell
• A19 Amacrine Cell

GABA-producing Cells

• GABAergic Axon-bearing Amacrine Cells

GABA-responsive Cells

• GABAergic Axon-bearing Amacrine Cells
• Invaginating Midget Bipolar
• supresses On-Y ganglion cells (Boos, Muller and Wassle, 1990)
• does not alter On-x or Off-x ganglion cells (Kirby and Enroth-Cugell, 1976)

Receptor Classes

• GABA a
• GABA b
• GABA c
• GABA rho

Antagonists

• Picrotoxin - Frishman & Linsenmeier (1982)
• Bicuculline (Hille)

Potentiator

• Barbiturates (Hille)
• Benzodiazepines (Hille)
• Alcohol (Hille)
• Glutamate (Hille)
• [3H]muscimol - agonist (Pourcho and Goebel, 1983 as cited in Vaney)
• Baclofen antagonizes Gaba b - ARVO '96 ?

GABA maintenance

• GAD is a GABA-synthesizing enzyme
• GABA-T (GABA-transaminase) - metabolizing enzyme

Permeability

• Anions (Hille)

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© 1995 Lance Hahn (lance@retina.anatomy.upenn.edu)